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Duchenne myopathy: Myogenesis modelled by human pluripotent stem cells, a multi‐omic study of disease early onset.

  We are proud to share the new publication by Virginie Mournetas and the IStem “Muscle Diseases” team:     Mournetas V, et al (2021). Myogenesis modelled by human pluripotent stem cells: a multi‐omic study of Duchenne myopathy early onset. Journal of Cachexia, Sarcopenia and Muscle. doi : 10.1002/jcsm.12665   We invite you to visit … [Read more]

My thesis in 180s’ 2020 : Élise Hérardot

    Doctoral student in Immunology at IStem, Élise Herardot is interested in the “reconstitution of a retina by bioengineering based on human pluripotent stem cells for the treatment of diseases affecting vision” alongside Karim Ben M’Barek and Christelle Monville. In this context, she took part in the final of Ma Thèse en 180s at … [Read more]

Stem cells: just 10 years from research to first clinical trials

I-Stem research laboratory was celebrating its 10 years in cell therapy R & D last October 27th in Paris: the right time to organize a press conference gathering international top medical opinion leaders in order to make an update on their pioneering work and the major steps forward to innovative stem cell therapies. Cross funded … [Read more]

Production of human motor neurons from stem cells is gaining speed

Researchers at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem – Inserm/AFM/UEVE) have recently developed a new approach to produce different populations of motor neurons from these cells in only 14 days.  Read the press release   << Return to the section “Press releases”

Progeria : Discovery of the molecular mechanism that preserves neural cells from accelerated ageing

Xavier Nissan’s research team at the Institute for Stem cell Therapy and Exploration of Monogenic Diseases (I-Stem), has identified a molecular mechanism that preserves neural cells from accelerated ageing in progeria. This work, conducted in collaboration with Nicolas Levy’s research team (Inserm/UMRS910, La Timone Faculté de Médecine, Université de la Méditerranée), was achieved by using … [Read more]

Identification of a recurrent chromosomal anomaly in neural cells derived from pluripotent stem cells (ES and iPS).

At a time when the first regenerative medicine clinical trials are being performed using pluripotent stem cells, teams from the I-Stem Institute, are continuing to explore the quality criteria that must be adopted to best ensure patient safety. Three years ago, an I-Stem team identified a genomic anomaly that very frequently appeared in undifferentiated cell … [Read more]

Skin pigmented using stem cells

Having successfully reconstructed an epidermis using pluripotent stem cells in 2009, Christine Baldeschi’s team at I-Stem, has just given it colour: using the same strategy, the researchers have obtained, in vitro, functional melanocytes, the cells that give skin its pigment and protect it from UV rays. This unlimited cell resource could, in time, be proposed … [Read more]

French Bioethics law : definitive adoption of the bioethics law on the embryonic stem cells research (june, 23rd, 2011)

A new scientific first through use of human embryonic stem cells

For the first time, through the use of human embryonic stem cells (hES) sourced from pre-implantation diagnosis, researchers from Inserm’s Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem) have successfully identified the previously unknown mechanisms involved in Steinert’ disease, also known as type 1 myotonic dystrophy. This work was published on 31 … [Read more]

First reconstitution of epidermis from human embryonic stem cells

Research on stem cells is advancing with giant steps. The Genodermatoses team has just succeeded in the challenge to re-create the ensemble of human human epidermis from human embryonic stem cells.This work  has been published in the journal Lancet. These researches have notably been financed thanks to donations to the Telethon.  Read the press release … [Read more]