What if the next generation of successful treatments was hidden in the current pharmacopoeia?
Identifying new indications for existing drugs, also called the drug repurposing or drug rediscovery process, is a highly efficient and low-cost strategy. First reported almost a century ago, drug repurposing has emerged as a valuable therapeutic option for diseases that do not have specific treatments and rare diseases, in particular.
This review focuses on Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder that induces accelerated and precocious aging, for which drug repurposing has led to the discovery of several potential treatments over the past decade.
Solenn M Guilbert, Déborah Cardoso, Nicolas Lévy, Antoine Muchir et Xavier Nissan
DOI (link) : 10.1016/j.ymeth.2020.04.005