Publications scientifiques 2016

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.

Cell Death Dis. 2016 Feb 18;7:e2105. doi: 10.1038/cddis.2015.374.

Blondel S, Egesipe AL, Picardi P, Jaskowiak AL, Notarnicola M, Ragot J, Tournois J, Le Corf A, Brinon B, Poydenot P, Georges P, Navarro C, Pitrez PR, Ferreira L, Bollot G, Bauvais C, Laustriat D, Mejat A, De Sandre-Giovannoli A, Levy N, Bifulco M, Peschanski M, Nissan X.

 

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells.

PLoS One. 2016 Feb 10;11(2):e0148680. doi: 10.1371/journal.pone.0148680. eCollection 2016.

Lopes C, Aubert S, Bourgois-Rocha F, Barnat M, Rego AC, Déglon N, Perrier AL, Humbert S.

 

Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism : A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome.

EBioMedicine. 2016 Jul;9:293-305. doi: 10.1016/j.ebiom.2016.05.032. Epub 2016 May 27.

Darville H, Poulet A, Rodet-Amsellem F, Chatrousse L, Pernelle J, Boissart C, Héron D, Nava C, Perrier A, Jarrige M, Cogé F, Millan MJ, Bourgeron T, Peschanski M, Delorme R, Benchoua A.

 

A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells.

Sci Rep. 2016 Oct 14;6:34798. doi: 10.1038/srep34798

Lo Cicero A, Jaskowiak AL, Egesipe AL, Tournois J, Brinon B, Pitrez PR, Ferreira L, de Sandre-Giovannoli A, Levy N, Nissan

X.

 

Metformin decreases progerin expression and alleviates pathological defects of Hutchinson-Gilford progeria syndrome cells.

NPJ Aging Mech Dis. 2016 Nov 10;2:16026. doi: 10.1038/npjamd.2016.26. eCollection 2016.

Egesipe AL, Blondel S, Cicero AL, Jaskowiak AL, Navarro C, Sandre-Giovannoli A, Levy N, Peschanski M, Nissan X.