High Throughput Screening
Team :
Marc Lechuga : HTS Lab head (CECS)
Yves Maury : Associate engineer (CECS)
Pauline Poydenot : Associate engineer (CECS)
Benjamin Brinon : Qualified research technician (CECS)
The principle of High Throughput Screening (HTS) is the selection among several hundreds thousands of molecules of those that could have a pharmaceutical fate.
The screening needs relevant biological models of genetic disease to test the molecules on and the technology of detection and dosage to observe the effect of these molecules. The HTS at Istem had focused on models based on stem cells.
The discovery of new pharmaceutical molecules against monogenic diseases is thus statistically optimized because of very great number that lead to the use of automates.
The screening needs relevant biological models of genetic disease to test the molecules on and the technology of detection and dosage to observe the effect of these molecules. The HTS at Istem had focused on models based on stem cells.
The discovery of new pharmaceutical molecules against monogenic diseases is thus statistically optimized because of very great number that lead to the use of automates.
The cell culture automation:
I-Stem fit its HTS laboratory out of an automated cell culture system allowing possible the handling and the screening of large chemical libraries of pharmaceutical interest. This automate makes also possible to handle under sterile and reproducible conditions nearly 200 plates (96 to 384 wells/plate) that make reach approximately amounts of 10000 to 40000 tests per screening campaign.
