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Stem cells: just 10 years from research to first clinical trials

I-Stem research laboratory was celebrating its 10 years in cell therapy R & D last October 27th in Paris: the right time to organize a press conference gathering international top medical opinion leaders in order to make an update on their pioneering work and the major steps forward to innovative stem cell therapies. Cross funded … [Read more]

Production of human motor neurons from stem cells is gaining speed

Researchers at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem – Inserm/AFM/UEVE) have recently developed a new approach to produce different populations of motor neurons from these cells in only 14 days.  Read the press release   << Return to the section “Press releases”

Progeria : Discovery of the molecular mechanism that preserves neural cells from accelerated ageing

Xavier Nissan’s research team at the Institute for Stem cell Therapy and Exploration of Monogenic Diseases (I-Stem), has identified a molecular mechanism that preserves neural cells from accelerated ageing in progeria. This work, conducted in collaboration with Nicolas Levy’s research team (Inserm/UMRS910, La Timone Faculté de Médecine, Université de la Méditerranée), was achieved by using … [Read more]

Identification of a recurrent chromosomal anomaly in neural cells derived from pluripotent stem cells (ES and iPS).

At a time when the first regenerative medicine clinical trials are being performed using pluripotent stem cells, teams from the I-Stem Institute, are continuing to explore the quality criteria that must be adopted to best ensure patient safety. Three years ago, an I-Stem team identified a genomic anomaly that very frequently appeared in undifferentiated cell … [Read more]

Skin pigmented using stem cells

Having successfully reconstructed an epidermis using pluripotent stem cells in 2009, Christine Baldeschi’s team at I-Stem, has just given it colour: using the same strategy, the researchers have obtained, in vitro, functional melanocytes, the cells that give skin its pigment and protect it from UV rays. This unlimited cell resource could, in time, be proposed … [Read more]

A new scientific first through use of human embryonic stem cells

For the first time, through the use of human embryonic stem cells (hES) sourced from pre-implantation diagnosis, researchers from Inserm’s Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem) have successfully identified the previously unknown mechanisms involved in Steinert’ disease, also known as type 1 myotonic dystrophy. This work was published on 31 … [Read more]

First reconstitution of epidermis from human embryonic stem cells

Research on stem cells is advancing with giant steps. The Genodermatoses team has just succeeded in the challenge to re-create the ensemble of human human epidermis from human embryonic stem cells.This work  has been published in the journal Lancet. These researches have notably been financed thanks to donations to the Telethon.  Read the press release … [Read more]

I-Stem and Roche form research collaboration to discover new therapies for diseases such as Alzheimer’s and schizophrenia

I-Stem, the Institute for Stem cell Therapy and Exploration of Monogenic Diseases, has signed an agreement with Swissbased healthcare company Roche to use I-Stem’s technologies in discovering novel therapies to treat devastating central nervous system (CNS) diseases such as Alzheimer’s, schizophrenia, depression and anxiety.  Read the press release   << Return to the section “Press … [Read more]

First innovative screens using stem cells to identify drugs for myotonic dystrophy, DM1 disease

Four research teams of I-Stem have joined forces in a collaborative project that has just achieved a first pilot therapy-oriented screen of compounds and RNA interference aiming at reversing the altered phenotypes observed in human embryonic stem cells carrying the mutant gene for myotonic dystrophy type 1. This assay inaugurates a series of R&D planned … [Read more]

Stem cell proliferation: towards a better understanding of the cell processes linked to cancers?

In work published on 24 November in the journal Nature biotechnology, Anselme Perrier’s team at I-Stem identified a recurrent anomaly in the genome of human embryonic stem cells left in culture for too long. Whether or not by chance, this same anomaly is found in a certain number of cancers. This discovery leaves open the … [Read more]